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Anonny

"...we know that this subset is not represented in these vaccine trials."

I was thinking about this myself awhile ago. The participants of a clinical study are randomly assigned a treatment and control, but the participants themselves are not randomly recruited, they are self-selected. So they're not really "randomized". It makes sense that most of the placebo group would go on to get the vaccine; the anti-vax or vax-hesitant are much less likely to sign themselves up for a clinical trial, I imagine.

I guess this means that clinicians need to apply some form of sampling bias correction, even for "randomized" trials, if they aren't already.

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