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Ken

My guess is that psychologists are having problems with things that people working with medical data have been aware of for a long time. Essentially ITT is correct because it reflects what happens to real patients. They get given a treatment and then there is some eventual outcome. They may switch treatments or whatever, but what matters is the initial choice of treatment. If we want to look at situations where we compare different alternative pathways through the various treatments, then we can define them as possible groups to be allocated to.

Where PP and other analyses may be useful is when we are interested in mechanisms and to see what may happen under different scenarios. We can try and estimate what will happen if we reduce dropouts, but that may not have a lot of relevance to the real world.

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