« Small numbers and scams | Main | The old is the new new thing »

Comments

Feed You can follow this conversation by subscribing to the comment feed for this post.

Jay

Please clarify your last sentence. It would seem that GSK is pretty hosed.

Kaiser

Jay: GSK's spokesman is "worried" that the new studies do not have the same credibility as their own clinical trials. I'm sure he/she is very worried about the prospect of Avandia! Sorry - the tongue in cheek doesn't translate well on line.

J

You should probably qualify your statement about sample sizes; a meta-analysis across studies involving 200k people total is not the same as one study of 200k people (I guess in theory they could be equivalent, if each study was conducted exactly the same - but that's not really a "meta-analysis").

The takeaway is that large sample sizes doesn't (always) trump design considerations.

Kaiser

J: agree that larger sample size is not always better. However, in this case, I believe that the spokesman is setting up a straw man. There are practical limitations to how large the sample size could be for a clinical trial. If multiple trials are available, a meta-analysis can help pool the information. It's by no means foolproof but I'd believe the pooled analysis of 56 trials more than the one trial GSK deems to be "well-designed".

Verify your Comment

Previewing your Comment

This is only a preview. Your comment has not yet been posted.

Working...
Your comment could not be posted. Error type:
Your comment has been posted. Post another comment

The letters and numbers you entered did not match the image. Please try again.

As a final step before posting your comment, enter the letters and numbers you see in the image below. This prevents automated programs from posting comments.

Having trouble reading this image? View an alternate.

Working...

Post a comment

Marketing and advertising analytics expert. Author and Speaker. Currently at Vimeo and NYU. See my full bio.

Next Events

Aug: 20 DataViz New York Meetup

Aug: 26 Optimizely Experience, Invited Expert, New York

Past Events

See here

Junk Charts Blog



Link to junkcharts

Graphics design by Amanda Lee

Search3

  • only in Big Data

Community